Relationship between serum concentrations of lipoprotein(a),Apelin-13,TGF-β1 and left atrial diameter in patients with atrial fibrillation
Objective To explore the relationship between serum lipoprotein(a),Apelin-13,and transforming growth factor beta 1(TGF-β1)and left atrial diameter(LAD)in patients with atrial fibrillation(AF).Methods A total of 100 patients who were admitted to Chuzhou First People's Hospital between December 2022 and January 2024 were selected as research objects.There were 50 patients with AF(AF group)and 50 patients without AF(NAF group).Serum levels of lipoprotein(a),Apelin-13,and TGF-β1 were detected,and LAD were measured by transthoracic echocardiography.Results Compared with those in the NAF group,lipoprotein(a),TGF-β1 and LAD were increased significantly in the AF group,while Apelin-13 was decreased significantly(P<0.05).Multivariable logistic regression revealed that lipoprotein(a),TGF-β1,diastolic blood pressure and LAD were risk factors of AF,while Apelin-13 was a protective factor of AF(P<0.05).Furthermore,lipoprotein(a),TGF-β1,LAD and Apelin-13 had predictive value for AF(P<0.05).Linear regression results showed that the coefficients of lipoprotein(a),TGF-β1 and Apelin-13 influencing on LAD were 0.01(P>0.05),-0.04(P>0.05)and-1.22(P<0.05),respectively.Conclusion Lipoprotein(a),TGF-β1 and LAD are independent risk factors of AF.However,lipoprotein(a)and TGF-β1 have no notable relation with LAD.As an independent protective factor of AF,Apelin-13 is significantly negatively correlated with LAD.
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