Hemostatic effect of a novel mammalian-derived bioadhesive
Objective To explore the hemostatic effect of a novel mammalian-derived bioadhesive in partial liver resection in rats.Methods The model of the left lateral lobectomy in SD rats established earlier was used in this study.The rats were divided into model group,test group and positive control group,with 10 rats in each group.The novel mammalian-derived bioadhesive and porcine fibrin sealant were sprayed on the wound in the test group and positive control group,respectively.The hemostatic effect was evaluated by calculating the amount and time of bleeding.Results Compared with the model group[(504.6±190.0)s,(194.4±144.2)mg],the bleeding time[(96.1±26.4)s,(4.8±17.8)mg]and the amount of bleeding[(156.7±139.3)s,(47.8±121.3)mg]were significantly shortened in the test group and positive control group(P<0.01).There was no significant difference in the bleeding time and the amount of bleeding between the positive control group and test group(P>0.05).Conclusion The novel mammalian-derived bioadhesive can reduce bleeding and shorten bleeding time in rat models with partial liver resection.In clinical practice,it can reduce hemostatic procedures,thereby shortening the surgical time and achieving the goal of sealing and hemostasis
NETL
NSTL
万方数据
