摘要
目的 系统评价学龄期哮喘患儿症状控制的影响因素.方法 计算机检索数据库Cochrane Library、CINAHL、PubMed、WOS、Embase、Medline、中国生物医学文献数据库、中国知网、万方数据知识服务平台、维普中文科技期刊数据库中有关学龄期患儿哮喘控制的横断面研究和队列研究,文献检索时限为建库至 2024 年 3 月 15 日.结果 共纳入 9 项研究,总样本量 5 016 例,Meta分析结果显示,学龄期哮喘患儿症状的影响因素有 7 项,其中呼出气一氧化氮水平高[OR=1.02,95%CI(1.01,1.03),P＜0.001]、哮喘家族史[OR=1.46,95%CI(1.17,1.83),P=0.002]、烟草暴露[OR=3.06,95%CI(1.48,6.31),P=0.002]、家长受教育水平低[OR=2.90,95%CI(1.61,5.25),P＜0.001]是学龄期哮喘患儿症状控制的危险因素;年龄较大[OR=0.91,95%CI(0.83,0.99),P=0.041]、开展哮喘相关讲座[OR=3.07,95%CI(1.43,6.60),P=0.004]、坚持使用药物[OR=0.81,95%CI(0.77,0.85),P＜0.001]、与父母同住[OR=0.94,95%CI(0.89,0.98),P=0.010]是学龄期哮喘患儿症状控制的保护因素.结论 呼出气一氧化氮检测的水平、哮喘家族史、烟草暴露、家长受教育水平、年龄、哮喘相关讲座、坚持使用药物是学龄期患儿哮喘控制的影响因素,未来应采取针对性措施提高学龄期患儿哮喘控制水平.
Abstract
Objective To systematically evaluate the influencing factors of symptom control in school-age children.Methods Cross-sectional studies and cohort studies on school-age asthma control were searched in the databases Cochrane Library,CINAHL,PubMed,WOS,Embase,Medline,China Biology Medicine disc,CNKI,Wanfang Data Knowledge Service Platform,and VIP Chinese Citation Database,and the literature search period was from inception to March 15,2024.Results A total of 9 studies were included,with a total sample size of 5 016 cases.The results of Meta-analysis showed that there were 7 statistically significant influencing factors in school-age children with asth-ma,among which high level of exhaled nitric oxide(FeNO)[OR=1.02,95%CI(1.01,1.03),P＜0.001],family history of asthma[OR=1.46,95%CI(1.17,1.83),P=0.002],tobacco exposure[OR=3.06,95%CI(1.48,6.31),P=0.002],low parental education level[OR=2.90,95%CI(1.61,5.25),P＜0.001]were risk factors for symptom control in school-age children with asthma.While older age[OR=0.91,95%CI(0.83,0.99),P=0.041],lectures on asthma[OR=3.07,95%CI(1.43,6.60),P=0.004],adherence to medication[OR=0.81,95%CI(0.77,0.85),P＜0.001],live with parents[OR=0.94,95%CI(0.89,0.98),P=0.010]were protective factor for symptom control in school-age children with asthma.Conclusion The level of exhaled nitric oxide,family history of asthma,tobacco exposure,parental education level,age,asthma-related lectures,and adherence to medication are the influencing factors of asthma control at school age.Targeted measures should be taken to improve the level of asthma control at school age in the future.
维普
万方数据