Forkhead transcription factor 3(FOXP3)played an important role in regulating regulatory T cell development and inhibiting function in normal physiological and stressed biological environments.The physical and chemical properties of FOXP3 protein,its crystal structure,post-translational modification and its interacting proteins were investigated using bioinformatics online tools and software.It was found that FOXP3 protein complex mainly contained the NFAT1 DNA-binding domain and the FOXP3 FKH domain bound to DNA,and affected the conformation of FOXP3 protein and its interaction with proteins through various post-translational modifications,and finally changed FOXP3 protein activity to regulate the inhibition of Treg.The results might provide a reference for further research on how FOXP 3 regulates the inhibition of Treg and new therapies to enhance immune tolerance in autoimmune diseases.
国家科技期刊平台
NSTL
维普
万方数据
