Effects of Quercetin on Serum and Intestinal Antioxidant Indices and Intestinal Barrier Function in Weaned Lambs
To explore the effects of quercetin on serum and intestinal antioxidant indices and intestinal barrier function in weaned lambs,twelve weaned lambs with body weight of(7.17±0.34)kg were randomly assigned to two groups.Lambs in 2 groups were fed basal diets supplemented with 0(Con group)and 100 mg·kg-1 BW quercetin(Que group),respectively.The experimental period lasted for 21 days.The results showed as follows:the serum glutathione peroxidase(GSH-Px)activity in the Con group of lambs was significantly lower than that in the Que group(P＜0.05).There was no significant difference in serum total antioxidant capacity(T-AOC),superoxide dismutase(SOD)activity,catalase(CAT)activity(P＜0.05),and malondialdehyde(MDA)content between the two groups(P>0.05).The activities of GSH-Px and SOD in the jejunal tissue of lambs in the Con group were significantly lower than those in the Que group(P＜0.05),and the MDA content was significantly higher than that in the Que group(P＜0.05).The MDA content in the ileum tissue was significantly higher than that in the Que group(P＜0.05).The relative expression level of Occludin in jejunal tissue in Con group was significantly lower than that in the Que group(P＜0.05).These results indicated that quercetin at a dose of 100 mg·kg-1 BW could improve antioxidant capacity and intestinal barrier function of weaned lambs.
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