Mechanism Prediction and Potential Target Exploration of Engeletin in the Treatment of Psoriasis Based on Network Pharmacology and Molecular Docking
Based on network pharmacology and molecular docking,the potential target and mechanism of engeletin in the treatment of psoriasis were investigated.First,potential targets of drugs and diseases were obtained through databases such as TCMSP.Secondly,a protein interaction network was constructed and key targets were obtained.GO functional enrichment analysis and KEGG pathway enrichment analysis were performed for intersection targets using Metascape database.Finally,the key target was selected for molecular docking with engeletin.The results showed that there were a total of 66 potential targets for the treatment of psoriasis,involving the regulation of inflammatory response,response to exogenous stimuli and other biological processes,and it might play a therapeutic role by regulating several signaling pathways such as PI3K/Akt.Molecular docking results showed that the binding activity of engeletin to the core target was good.It elucidated that engeletin could treat psoriasis by multi-target and multi-pathway,which provided a theoretical basis for developing new drugs for psoriasis.
万方数据
维普
