黑龙江八一农垦大学学报2024，Vol.36Issue(5) ：112-118,136.DOI:10.3969/j.issn.1002-2090.2024.05.015

MCM-48纳米颗粒作为小核酸载体的性能研究

Research on the Performance of MCM-48 Nanoparticles as Delivery Vectors for Small Nucleic Acid

叶凌涛 王羽 李育霖 杨迪 刘佳滢 魏芳桐 孙艳
黑龙江八一农垦大学学报2024，Vol.36Issue(5) ：112-118,136.DOI:10.3969/j.issn.1002-2090.2024.05.015
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MCM-48纳米颗粒作为小核酸载体的性能研究

Research on the Performance of MCM-48 Nanoparticles as Delivery Vectors for Small Nucleic Acid

叶凌涛 1王羽 1李育霖 1杨迪 1刘佳滢 1魏芳桐 1孙艳1
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作者信息

  • 1. 黑龙江八一农垦大学生命科学技术学院,大庆 163319
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摘要

合成制备了MCM-48 型的介孔纳米颗粒,对其进行了系统的物化表征,表明其是具有高比表面积、高度有序结构和三维特征孔道特点的纳米颗粒.对MCM-48 纳米颗粒进行氨基化修饰,得到N-MCM-48 纳米颗粒,研究了其作为小核酸载体的性能.结果显示:N-MCM-48 纳米颗粒具有良好的吸附和释放小核酸的能力、细胞摄入能力和生物相容性,并能够负载siRNA进入HepG2 细胞并诱导肿瘤细胞凋亡.

Abstract

MCM-48 silica nanoparticles were prepared and characterized,which showed a highly ordered mesoporous structure with Ia3d crystal lattice.The MCM-48 nanoparticles were modified with NH2-group,as N-MCM-48 nanoparticles.N-MCM-48 nanoparticles were researched as delivery vectors for small nucleic acid.The results indicated that the N-MCM-48 nanoparticles had good adsorption and release of small nucleic acid capabilities,cell uptake ability,and biocompatibility,and could load siRNA into HepG2 cells and induce tumor cell apoptosis.

关键词

MCM-48/介孔纳米颗粒/小核酸载体

Key words

MCM-48/nanoparticles/delivery vectors for small nucleic acid

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基金项目

黑龙江八一农垦大学科研启动基金(XYB201920)

黑龙江八一农垦大学基础培养基金(ZRCPY202032)

黑龙江省"双一流"新一轮建设学科协同创新成果建设项目(LJGXCG2022-006)

出版年

2024
黑龙江八一农垦大学学报
黑龙江八一农垦大学

黑龙江八一农垦大学学报

影响因子：0.888
ISSN：1002-2090
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