Research on the Performance of MCM-48 Nanoparticles as Delivery Vectors for Small Nucleic Acid
MCM-48 silica nanoparticles were prepared and characterized,which showed a highly ordered mesoporous structure with Ia3d crystal lattice.The MCM-48 nanoparticles were modified with NH2-group,as N-MCM-48 nanoparticles.N-MCM-48 nanoparticles were researched as delivery vectors for small nucleic acid.The results indicated that the N-MCM-48 nanoparticles had good adsorption and release of small nucleic acid capabilities,cell uptake ability,and biocompatibility,and could load siRNA into HepG2 cells and induce tumor cell apoptosis.
MCM-48nanoparticlesdelivery vectors for small nucleic acid
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