In order to realize real-time monitoring,data sharing and collaborative work between various devices in the intelligent manufacturing industry,the study analyzes the serial communication and MC protocol communication between Mitsubishi small PLC and computer under NET Core7.0 environment,develops Mitsubishi PLC communication management system,successfully realizes the host computer to the field PLC data acquisition and remote operation,and conducts data analysis and processing with cloud database technology and database management tools.In this way,the real-time monitoring and fault analysis of the equipment are realized.