Traditional Chinese medicine(TCM)is a complex system of multi-components and multi-targets,which is a precious resource accumulated by Chinese civilization for thousands of years.However,due to the lack of toxicity studies on TCM,the safe range of its use is unclear,which limits its wide use and promotion.Therefore,the toxicity evaluation of each TCM monomer is particularly important.Zebrafish is an important vertebrate model for low-cost in vivo whole-organism midthroughput drug screening and toxicology studies.The study reviews the research progress of the detection of cardiotoxicity,hepatotoxicity,neurotoxicity and developmental toxicity of various TCM monomers by zebrafish;and points out the existing problems in the study of toxicity of TCM monomers.Zebrafish is an ideal model organism for toxicity and safety evaluation of traditional Chinese medicine monomers.In the future,standards and high-throughput determination methods should be established to evaluate the safety of thousands of traditional Chinese medicine monomers.
关键词
中药单体/斑马鱼/心脏毒性/肝毒性/神经毒性
Key words
Monomer of Chinese traditional herbs/Zebrafish/Cardiotoxicity/Hepatotoxicity/Neurotoxicity
维普
万方数据