NLRP3炎性小体在神经退行性疾病中的作用
Role of the NLRP3 Inflammasome in Neurodegenerative Diseases
汪尚 1张婷婷 2王凯1
作者信息
- 1. 南京医科大学康达学院人体解剖学教研室,江苏连云港 222000
- 2. 南京医科大学康达学院临床医学部,江苏连云港 222000
- 折叠
摘要
Nod样受体蛋白3是细胞内固有免疫系统中识别病原菌的重要受体,主要在中枢神经系统的小胶质细胞中表达.小胶质细胞可通过激活NLRP3炎性小体释放炎性因子引起细胞凋亡,参与神经退行性疾病的发生发展过程.证明NLRP3炎症小体与神经退行性疾病之间存在密不可分的联系,抑制NLRP3炎性小体的激活对AD和其他NDs具有保护作用,并改善患者的认知能力.
Abstract
Nod-like receptor protein 3 is an important receptor for the recognition of pathogens in the intracellular innate immune system.It is mainly expressed in microglia of the central nervous system.Microglia can induce apoptosis by activating the NLRP3 inflammasome to release inflammatory factors and participate in the occurrence and development of neurodegenerative diseases.There is close relationship between NLRP3 inflammasome and neurodegenerative diseases.Inhibition of the activation of the NLRP3 inflammasome has protective effect on AD and other NDs,and improves cognitive function in patients.
关键词
NLRP3炎性小体/神经退行性疾病/潜在价值Key words
NLRP3 inflammasome/Neurodegenerative diseases/Potential value引用本文复制引用
基金项目
南京医科大学康达学院科研发展基金课题(KD2022KYJJZD053)
出版年
2024
NETL
NSTL
万方数据