PRPF8 encodes the catalytic center in the alternative splicing process,which can interact with U5 snRNP and 5'and 3'splicing sites,promote the assembly of spliceosomes,and participate in multiple key steps in the alternative splicing process.The abnormity of PRPF8 will lead to the development of many physiological or pathological diseases,including cancer.The study reviews the basic structure and function of PRPF8,summarizes the relationship between PRPF8 and various cancers,and prospects the application prospect in clinics.
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