According to the noise characteristics of the pulse wave signal and denoising demand,the study proposes a denoising method and mathematical morphology filtering and SG sliding filter pulse wave signal based method.The baseline drift of pulse wave is removed by morphological filters,and then the high frequency interference signal of pulse wave signal is eliminated by SG smoothing filter.The experimental results show that the proposed method can effectively eliminate the baseline drift of pulse wave signal and the high frequency interference,so as to lay a good foundation for the pulse wave signal feature extraction and accurate measurement of blood oxygen saturation.