Triple-negative breast cancer(TNBC)is the most aggressive molecular subtype of breast cancer,accounting for 10％～15％of all breast cancers.It has the worst prognosis.It is characterized by lack of estrogen receptor(ER)and progesterone receptor(PR)expression,human epidermal growth factor receptor 2(ERBB2/HER2)overexpression or gene amplification,so early TNBC is considered to be an estrogen-independent breast cancer.The treatment of breast cancer mainly includes hormone therapy,anti-HER2 therapy and chemotherapy.So TNBC has lacked effective targeted therapy and precise treatment options for a long time.Until the discovery of G protein-coupled estrogen receptor(GPER),the estrogen-mediated pathway of TNBC is revealed.Some studies have shown that GPER is related with TNBC promoting metastasis pathway.These results provide new insights into the carcinogenic effect of GPER mediating estrogen in TNBC,and provide new ideas for the treatment of TNBC.The study reviews the pathways related with GPER and their rationality as potential therapeutic targets for TNBC,so as to provide a theoretical basis for exploring the effective pathways for TNBC treatment.
关键词
三阴性乳腺癌/G蛋白偶联雌激素受体/雌激素/信号通路
Key words
Triple-negative breast cancer/G protein-coupled estrogen receptor/Estrogen/Signal path
维普
万方数据