Factors Influencing Severe Infection after Chemotherapy for Childhood Neuroblastoma and the Effect of Recombi-nant Human Granulocyte-stimulating Factor Prophylaxis
Objective:To analyze and investigate the factors influencing severe infection after chemotherapy for neuroblastoma(NB)in children and the effect of the application of recombinant human granulocyte-stimulating factor(rhG-CSF)for prevention to provide a clinical basis.Methods:The general data of 100 children with NB admitted to the hospital from March 2020 to December 2021 were retrospectively analyzed,and the incidence of serious infections after chemotherapy treatment in all children was counted,as well as the factors influencing the possible clinical triggers of infection.Children who received rhG-CSF prophylaxis 24 h after stopping chemotherapy were included as the observation group(n=57),and children who received rhG-CSF prophylaxis after the development of granulocyte deficiency were included as the control group(n=43).The occurrence of serious infections in the two groups was observed and the influencing factors were analyzed and the application effect of rhG-CSF prophylaxis was compared.Results:The incidence of serious infection among 100 children was 27.00%(27/100).univariate analysis of the incidence of serious infection after chemotherapy in children with NB showed that different children's age,stage of disease,distant metastases,serum NSE,surgical resection,chemotherapy drugs,and duration of chemotherapy affected the incidence of serious infection after chemotherapy in children with statistically significant differences(χ2=5.372,6.222,6.322,5.983,4.785,10.079,7.193,P＜0.05).After the application of rhG-CSF intervention treatment,the incidence of serious infection in the control group was higher than that in the observation group and lasted longer than that in the control group,and the difference was statistically significant(χ2=6.515;t=10.218,P＜0.05).Conclusion:The main factors affecting severe infections after chemotherapy in children with NB are age,clinical stage,serum NSE level,selected chemotherapy drugs,and duration of chemotherapy,etc.If rhG-CSF can be given in time after 24 h of chemotherapy,it can significantly reduce the probability of severe infections in the child population and help improve the prognosis of children.
Childhood neuroblastomaChemotherapy treatmentSevere infectionInfluencing factorsRecombinant human granulocytesStimulating factorProphylactic application
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