Objective:To observe the effect of dexmedetomidine in general anesthesia for laparoscopic hysterectomy,and to analyze the effect on patients'hemodynamics,stress reaction and awakening.Methods:135 patients who underwent laparoscopic hysterectomy treatment admitted to the hospital from January 2020 to January 2022 were selected as the study subjects,and the pa-tients were divided into the conventional group(n=67,general anesthesia was applied intraoperatively via implementation of general anesthesia)and the study group(n=68,dexmedetomidine was applied on the basis of general anesthesia as an adjuvant)by using the lottery method.Hemodynamics,stress levels and quality of awakening were compared between the two groups.Results:Postop-eratively,SPO2 and PaO2 of patients in the study group were higher than those in the conventional group,and MAP and PaCO2 were lower than those in the conventional group,with statistically significant differences(t=11.234,9.098,5.400,2.900,P＜0.05).Hydrogen peroxide(CAT)and glutathione peroxidase(GSH-Px)were higher and malondialdehyde(MDA)and cortisol(Cor)were lower in the study group than in the conventional group,and the difference was statistically significant(t=20.238,19.242,3.992,12.745,P＜0.05).The NRS,BPS,RASS,and SAS scores of the patients in the study group were lower than those of the conventional group,and the difference was statistically significant(t=15.678,8.660,30.521,16.681,P＜0.05).The difference in the occurrence of adverse events between the two groups was not statistically significant(χ2=0.495,P＞0.05).Conclusion:The use of dexmedeto-midine to assist patients during minimally invasive hysterectomy anesthesia can effectively control their hemodynamics,inhibit post-operative stress,and have a positive effect on improving the quality of patients'awakening.dexmedetomidine has a fair safety profile and does not significantly increase the risk of adverse events.
Laparoscopic hysterectomyDexmedetomidineGeneral anesthesiaHemodynamicsStress responseRecovery from anesthesia
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