Study on the Effect of Zopiclone Combined with Olanzapine on Sleep Quality and Serum NF-κB and 5-HT in Pa-tients with Schizophrenia with Sleep Disorders
Objective:To investigate the effects of zopiclone combined with olanzapine on sleep quality and serum nuclear tran-scription factor-κB(NF-κB)and 5-hydroxytryptamine(5-HT)in patients with schizophrenia with sleep disorders.Methods:82 cases of schizophrenia with sleep disorder admitted to the hospital from April 2020 to April 2022 were selected as the study sub-jects,and were divided into the control group and the observation group according to the random number table method,with 41 cases in each group.Both groups were treated with aripiprazole,the control group was given olanzapine and the observation group was given olanzapine combined with zopiclone for 4 weeks.The Pittsburgh Sleep Quality Index(PSQI)scores,polysomnographic(PSG)monitoring tracings,serum NF-κB and 5-HT levels,clinical efficacy,and incidence of adverse effects were compared between the two groups.Results:After treatment,the PSQI score of the observation group was significantly lower than that of the control group,and the difference was statistically significant(t=4.339,P＜0.05).After treatment,the total sleep time,awakening time,REM sleep time,and SWS time of the observation group were longer than that of the control group,and the REM latency was shorter than that of the control group,with statistically significant differences(t=2.211,4.433,3.821,4.404,2.709,P＜0.05).After treatment,the NF-κB level of the observation group was lower than that of the control group,and the 5-HT level was higher than that of the con-trol group,and the difference was statistically significant(t=5.438,7.389,P＜0.05).The total clinical effectiveness rate of the ob-servation group was higher than that of the control group,and the difference was statistically significant(χ2=4.100,P＜0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(χ2=0.518,P＞0.05).Con-clusion:Zopiclone combined with olanzapine has better efficacy in the treatment of patients with schizophrenia with sleep disor-ders,which can improve patients'sleep quality and serum NF-κB and 5-HT levels,and alleviate their psychiatric symptoms,and is safe.
NETL
NSTL
万方数据
