Study of the Effect of Adjuvant Therapy with Selective Calcium Channel Antagonists on Serum Inflammatory Fac-tors and Intestinal Flora in Patients with Ulcerative Colitis
Objective:To explore the effects of adjuvant therapy with selective calcium channel blockers(SCCBs)on serum inflammatory factors and intestinal flora in patients with ulcerative colitis(UC).Methods:86 cases of UC patients admitted to the hospital from February 2018 to March 2020 were selected as the study subjects,and were divided into the reference group and the experimental group using the method of district group randomization,with 43 cases in each group.The reference group was treated with conventional therapy,and the experimental group was treated with appropriate SCCBs on the basis of the reference group.The serum inflammatory factor levels,intestinal flora levels and therapeutic efficacy of the two groups were compared before and after treatment.Results:After treatment,the levels of IL-6,IL-8,CRP and TNF-α were reduced in both groups,but the levels of IL-6,IL-8,CRP and TNF-α in the experimental group were significantly lower than those in the reference group,and the difference was statistically significant(t=6.735,8.374,7.518,6.840,P＜0.05).After treatment,the levels of lactobacilli,enterococci and bifidobacteria increased in both groups,but the levels of lactobacilli,enterococci and bifidobacteria in the experimental group were significantly higher than those in the reference group,and the difference was statistically significant(t= 9.612,9.381,6.187,P＜0.05).After treatment,the SOD level of the test group was significantly higher than that of the reference group,and the difference was statistically significant(t=7.549,P＜0.05).The MDA level of the test group was significantly lower than that of the reference group,and the difference was statistically significant(t=9.835,P＜0.05).Conclusion:SCCBs adjuvant therapy applied in UC patients can effectively alleviate the patients'body inflammatory response,regulate their intestinal flora,and promote the recovery of their normal physiological function of the colon.
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