Value of Preoperative Puncture Biopsy and Intraoperative Frozen Pathology for the Diagnosis of Ductal Carcinoma in Situ of the Breast with Microinfiltration
Objective:To investigate the diagnostic value of preoperative puncture biopsy and intraoperative frozen pathology techniques for the diagnosis of ductal carcinoma in situ with microinfiltration of the breast and to analyze disease characteristics.Methods:62 patients with ductal carcinoma in situ of the breast admitted to the hospital from February 2021 to February 2022 were selected,and all of them underwent preoperative puncture biopsy and intraoperative frozen pathologic examination.Postoperative pathology was used as the diagnostic gold standard and diagnostic efficacy of the two modalities,as well as the clinical features of the two diseases and the distribution status of tumor-infiltrating lymphocytes,was compared.Results:The results of postoperative pathologic studies showed that of the 62 patients,38 were patients with simple ductal carcinoma in situ of the breast and 24 were patients with ductal carcinoma in situ of the breast with microinvasion.The diagnostic sensitivity of preoperative puncture biopsy was 91.67%,specificity was 84.21%,accuracy was 87.10%,positive predictive value was 78.57%,and negative predictive value was 94.12%,which was higher than 58.33%,55.26%,56.45%,45.16%,and 54.74%of intraoperative frozen pathology,and the difference was statistically significant(χ2=7.111,7.544,14.370,6.904,7.494,P＜0.05).The diameter of breast ductal carcinoma in situ with microinvasive lesions was(3.21±0.54)cm,the probability of palpable mass was 95.83%,the probability of high expression of ki67 was 66.67%,the probability of high differentiation was 70.83%,which was higher than that of ductal carcinoma in situ of the breast,and the positivity rate of progesterone receptor was 17.86%,and the positivity rate of estrogen receptor was 29.17%,which was lower than that of ductal carcinoma in situ of the breast,and the differences were statistically significant(t=4.948,χ2=4.439,4.876,P＜0.05).Conclusion:Compared with intraoperative frozen pathology,preoperative puncture biopsy of mammary ductal carcinoma in situ with microinfiltration has high accuracy;mammary ductal carcinoma in situ with infiltration and mammary ductal carcinoma in situ with infiltration have different clinical features and distribution status of tumor infiltrating lymphocytes,which can provide the basis for differential diagnosis of the disease.
Preoperative puncture biopsyIntraoperative frozen pathologyDuctal carcinoma in situ of the breast with microinfiltrationDiagnostic efficacyClinical featuresTumor infiltrating lymphocytes
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