Effects of Early Intensive Cognitive Function Training on Cognitive Function,Serum S100β and NSE Levels in Pa-tients with Post-stroke Cognitive Dysfunction
Objective:To investigate the effects of post-stroke cognitive impairment(PSCI)patients on NSE levels,serum S100β and cognitive function after early intensive cognitive training intervention.Methods:129 cases of stroke PSCI patients ad-mitted to the hospital from June 2019 to December 2021 were selected as the study subjects,and were divided into 64 cases in the control group(conventional rehabilitation intervention)and 65 cases in the observation group(conventional rehabilitation interven-tion combined with early intensive cognitive feats)functional training according to the method of randomized numerical table.Both groups were treated for 6 months.Cognitive function(Montreal Cognitive Assessment Scale[MoCA]total score,attention,abstrac-tion and memory,and visuospatial executive ability scores before and after training),neurofactor levels(serum S100β and neu-ron-specific enolase[NSE]levels before and after training),and caregiving burden(caregiver burden assessed before and after the intervention by using the Caregiver Burden Inventory[ZBI]and Caregiver Positive Feelings Scale[PAC])were compared between the two groups.Results:After the intervention,the observation group had higher attention,abstraction,memory,and visuospatial execution scores than the control group,and the difference was statistically significant(t=7.723,11.873,4.519,7.954,P＜0.05).ZBI and PAC scores were higher in the observation group than in the control group,and the difference was statistically significant(t=8.083,14.165,P＜0.05).The levels of NSE and S100β in the observation group were lower than those in the control group,and the difference was statistically significant(t=25.694,4.824,P＜0.05).Conclusion:Conventional rehabilitation combined with early intensive cognitive functioning interventions for stroke patients with PSCI can effectively improve neurofactors,reduce the burden of care,and mitigate cognitive impairment.
Early intensive cognitive function trainingStrokeCognitive dysfunction
万方数据
维普
