Effect of Routine,Early Lung Expansion Therapy on the Rate of Pulmonary Atelectasis in Patients with Ventila-tor-assisted Ventilation in the ICU
Objective:To study the effect of routine and early lung expansion therapy on the rate of pulmonary atelectasis in pa-tients with ventilator-assisted ventilation in the ICU,and to provide a scientific basis for clinical treatment.Methods:120 patients undergoing treatment in the ICU of the hospital from January 2019 to January 2020 were selected as the study subjects,and they were divided into the observation group and the control group according to the principle of randomized grouping,with 60 cases in each group.Patients took conventional nursing measures,and patients in the observation group took the standard operation of venti-lator lung expansion on this basis,and both groups were treated for 2 weeks.The hospitalization,respiratory function parameters,hemodynamic index levels,oxidative stress response index levels,and inflammatory response index levels of patients in the two groups were compared.Results:The incidence of pulmonary atelectasis,success rate of extrication,ICU stay,and hospitalization time of the patients in the observation group were significantly lower than those in the control group,and the differences were statis-tically significant(χ2=6.012,4.357,P＜0.05;t=6.085,7.327,P＜0.05).After treatment,the tidal volume,lung compliance,and oxygenation index of the patients in the observation group were significantly higher than those of the control group,and the airway resistance,airway pressure,and respiratory work of the patients in the observation group were significantly lower than those of the control group,with statistically significant differences(t=34.128,21.323,30.699,2.941,4.992,3.015,P＜0.05).After treatment,the cardiac output(CO),mean arterial pressure,and central venous pressure of the patients in the observation group were signifi-cantly higher than those of the control group at 12 h and 24 h after treatment,and the heart rate(HR)of the patients in the obser-vation group were significantly lower than those of the control group at 12 h and 24 h after treatment,and the differences were sta-tistically significant(t=10.401,8.092,5.396,7.439,4.701,4.249,2.268,3.249,P＜0.05).After treatment,serum renin(Renin),an-giotensin II(ACEI II),epinephrine(E)and norepinephrine(NE)of patients in the observation group were significantly lower than those of the control group,and the difference was statistically significant(t=2.677,8.858,13.161,2.238,P＜0.05).After treatment,the levels of interleukin 4(IL-4),interleukin 10(IL-10),interferon(INF-γ)and tumor necrosis factor(TNF-α)in patients in the observation group were significantly lower than those in the control group,with statistically significant differences(t=8.674,12.195,2.001,30.019,P＜0.05).Conclusion:Patients on ventilator-assisted ventilation in the ICU are routinely and early treated with puffed lungs,and the rate of pulmonary atelectasis is significantly reduced in the patients.
Intensive care unitInflation treatmentAtelectasisOxidative stressInflammatory reaction
万方数据
维普
