Predictive Value and Clinical Significance of NLR,MLR,and PLR Change Levels on Cardiac Function in Patients with Heart Failure with Reduced Ejection Fraction
Objective:To investigate the predictive value and clinical significance of the level of changes in neutrophil-to-lymphocyte ratio(NLR),monocyte-to-lymphocyte ratio(MLR),and platelet-to-lymphocyte ratio(PLR)on cardiac function in patients with heart failure with reduced ejection fraction(HFrEF).Methods:225 patients with HFrEF admitted to the hospital from April 2019 to April 2022 were selected as the study group,and 160 patients hospitalized at the same stage and with the exception of heart failure were selected as the control group.General information,blood routine,biochemistry,and echocardiography at the time of admission were compared between the two groups.The correlation of NLR,MLR,and PLR with left ventricular ejection fraction(LVEF),left ventricular end-diastolic internal diameter(LVEDD),end-diastolic volume(EDV),end-systolic volume(ESV),and N-terminal B-type natriuretic peptide proteins(NT-proBNP)were calculated,and the predictive value of the three indices was analyzed by the ROC curve in patients with HFrEF.Results:The levels of NLR,MLR,PLR,LVEDD,EDV,and ESV in the HFrEF group were higher than those in the control group,and the difference was statistically significant(Z=-13.616,-9.413,-8.591,P＜0.001;t=20.202,12.684,24.312,P＜0.001).LVEF in the HFrEF group was lower than that in the control group,and the difference was statistically significant(t=-55.219,P＜0.001).NLR,MLR,and PLR were positively correlated with LVEDD,EDV,ESV,and NT-proBNP,and negatively correlated with LVEF,with statistically significant differences(P＜0.001).NLR had the highest predictive value in patients with HFrEF.Conclusion:NLR,MLR,and PLR have a certain relationship with the occurrence and development of HFrEF,and the higher the NLR,MLR,and PLR,the more severe the symptoms of heart failure in patients with HFrEF,which provides a certain reference for the clinical diagnosis and treatment of HFrEF.
Heart failureHeart failure with reduced ejection fractionNeutrophil to lymphocyte ratioMonocyte to lymphocyte ratioPlatelets and lymphocyte ratio
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