首页|围产期孕妇GBS感染情况及与不良妊娠结局及新生儿结局的相关性

围产期孕妇GBS感染情况及与不良妊娠结局及新生儿结局的相关性

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目的:分析围产期孕妇B族链球菌(GBS)感染情况及其与不良妊娠结局及新生儿结局的相关性.方法:选取2021年11月—2023年3月在郑州市妇幼保健院就诊的1 590例孕36~42周的孕妇作为研究对象,检测并统计围产期孕妇的GBS感染状况,并根据GBS感染情况,将孕妇进行分组.采用logistic回归分析围产期孕妇感染GBS的影响因素,比较两组孕妇的不良妊娠结局,对比两组的新生儿结局.结果:本研究的1 590例围产期孕妇中,共有84例(5.28%)GBS为阳性,1 506例(94.72%)GBS为阴性.阳性组及阴性组孕妇的平均年龄、平均孕周、平均产次等资料相比,差异无统计学意义(P>0.05);而两组孕妇的孕早期体质指数(BMI)、存在阴道炎、妊娠期糖耐量异常等资料相比,差异有统计学意义(t/x2=9.373、35.860、22.236,P<0.05).logistic多因素回归分析结果显示,孕早期BMI、存在阴道炎、妊娠期糖耐量异常为影响围产期孕妇感染GBS的独立危险因素(P<0.05).阳性组孕妇发生胎膜早破、宫内感染、产褥感染、产后出血等的概率均明显高于阴性组,差异有统计学意义(x2=6.939、24.067、27.741、35.902,P<0.05).阳性组发生胎儿宫内窘迫、早产、新生儿肺炎、脑膜炎、败血症、病理性黄疸等的概率均明显高于阴性组,差异有统计学意义(x2=5.434、52.989、9.394、17.940、17.940、7.354,P<0.05).结论:围产期孕妇出现GBS感染可明显增加不良妊娠结局的发生风险,因此,应对围产期孕妇开展GBS常规筛查,以保障母婴安全.若孕妇感染GBS,应尽早干预,以改善不良妊娠结局.
Perinatal GBS Infection in Pregnant Women,and its Correlation with Adverse Pregnancy Outcomes and Neonatal Outcomes
Objective:To analyze the infection of group B streptococcus(GBS)in perinatal pregnant women and its correlation with adverse pregnancy and neonatal outcomes.Methods 1 590 pregnant women at 36 to 42 weeks of gestation who were treated the hospital from November,2021 to March,2023 were selected as the research objects.GBS infection status of pregnant women during the perinatal period was detected and counted.The pregnant women were divided into groups according to GBS infection.The influencing factors of GBS infection in perinatal pregnant women were analyzed by logistic regression.The adverse pregnancy outcomes and neonatal outcomes of the two groups were compared,and the neonatal outcomes of the two groups were compared.Re-sults Among 1 590 perinatal pregnant women,84(5.28%)were GBS positive and 1 506(94.72%)were GBS negative.There was no significant difference in the average age,average gestational weeks and average parity between the positive group and the nega-tive group(P>0.05).There were statistically significant differences in body mass index(BMI),vaginitis and abnormal glucose tolerance during pregnancy between the two groups(t/x2=9.373,35.860,22.236;P<0.05).Logistic multivariate regression analysis showed that BMI,vaginitis and abnormal glucose tolerance in early pregnancy were independent risk factors for GBS infection in perinatal women(P<0.05).The incidence of premature rupture of membranes,intrauterine infection,puerperal infection and post-partum hemorrhage in the positive group was significantly higher than that in the negative group(x2=6.939,24.067,27.741,35.902;P<0.05).The incidence of fetal distress,premature birth,neonatal pneumonia,meningitis,septicemia,and pathological jaundice in the positive group were significantly higher than those in the negative group(x2=5.434,52.989,9.394,17.940,17.940,7.354;P<0.05).Conclusion GBS infection in perinatal pregnant women can significantly increase the risk of adverse pregnancy outcomes.Therefore,routine screening of GBS in perinatal pregnant women should be carried out to improve the safety of mother and child.Pregnant women infected with GBS should be intervened as soon as possible to improve adverse pregnancy outcomes.

Perinatal periodGroup B streptococcusAdverse pregnancy outcomesPremature rupture of membranesFetal dis-tress in uteroPremature rupture of fetal membranes

孙园圆、赵建萍

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郑州市妇幼保健院检验科,河南 郑州 450000

围产期 B族链球菌 不良妊娠结局 胎膜早破 胎儿宫内窘迫 胎膜早破

2024

黑龙江医学
中华医学会黑龙江分会

黑龙江医学

影响因子:0.714
ISSN:1004-5775
年,卷(期):2024.48(5)
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