Study of the Effects of Pemetrexed,Etoposide and Cisplatin Combined with Thoracic Radiotherapy on Long-term and Near-term Outcomes in Patients with Locally Advanced Lung Adenocarcinoma
Objective:To investigate the effects of pemetrexed,etoposide and cisplatin combined with thoracic radiotherapy on the long-term and near-term outcomes in patients with locally advanced lung adenocarcinoma.Methods:76 cases of locally ad-vanced lung adenocarcinoma patients admitted to the hospital from May 2017 to May 2020 were selected as the study subjects,and were divided into the control group and the observation group according to the method of random number table,with 38 cases in each group.Both groups were treated with chest radiotherapy,the control group was treated with etoposide combined with cisplatin(EP)chemotherapy regimen,and the observation group was treated with pemetrexed combined with cisplatin(PP)chemotherapy regimen.The clinical efficacy,serum tumor markers,survival quality and the occurrence of adverse reactions were compared between the two groups after 2 cycles of chemotherapy,and the long-term survival rate was recorded after 2 years of follow-up.Results:The disease control rate of the observation group was higher than that of the control group,and the difference was statistically sig-nificant(x2=4.094,P＜0.05).After treatment,the levels of CEA,CA125,and CYFRA21-1 in the observation group were lower than those in the control group,and the difference was statistically significant(t=4.992,4.861,6.715;P＜0.05).After treatment,the physical,psychological,environmental,and social scores in the quality of life of the observation group were higher than those of the control group,and the difference was statistically significant(t=4.747,5.004,5.138,4.744;P＜0.05).The long-term survival rate of the observation group was higher than that of the control group,and the difference was statistically significant(x2=4.413,P＜0.05).There was no statistically significant difference in the incidence rate of adverse reaction group between the two groups of pa-tients(x2=0.517,P＞0.05).Conclusion:PP combined with cisplatin simultaneous chest radiotherapy can enhance the therapeutic efficacy of patients with locally advanced lung adenocarcinoma,accelerate the normalization of tumor marker levels,increase the long-term survival rate of patients,and improve their quality of life.It is safe and reliable.
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