Study of Factors Affecting Lung Infections Complicated by Radiotherapy in Lung Cancer Patients
Objective:To analyze the influencing factors of lung infections complicating lung cancer patients after radiotherapy.Methods:The clinical data of 100 lung cancer patients admitted to the hospital from March 2020 to March 2022 who met the indi-cations of radiotherapy were retrospectively analyzed,and the occurrence of lung infections after radiotherapy and the distribution of pathogenic bacteria were counted.They were categorized into Group A(lung infection occurred)and Group B(no lung infection occurred)based on whether they had or had not developed a lung infection.The influencing factors that may affect the occurrence of lung infection were also analyzed.Results:A total of 21 patients(21.00%)of 100 lung cancer patients developed lung infections after radiotherapy.Among the 21 patients who developed lung infections,the pathogenic organisms with the highest distribution were Staphylococcus spp.(42.86%),followed by Klebsiella pneumoniae(28.57%),Pseudomonas spp.(19.05%),and fungi(9.52%),respectively.There was no statistically significant difference between the two groups in terms of gender and smoking history(x2= 0.004,1.584,P＞0.05).There was a statistically significant difference in terms of age between group A and group B(x2=8.765,P＜0.05).The difference was statistically significant when comparing the duration of radiotherapy between group A and group B(x2= 7.864,P＜0.05).The difference was statistically significant when comparing the chemotherapeutic drugs between group A and group B(x2=8.765,P＜0.05).There was a statistically significant difference between group A in terms of albumin content when compared to group B(x2=4.571,P＜0.05).There was a statistically significant difference between group A in terms of KPS score when compared to group B(x2=5.314,P＜0.05).The independent risk factors affecting the complication of lung infection after che-motherapy in patients were age＞55 years,duration of radiotherapy＞2 weeks,combination of chemotherapeutic agents,albumin level≤30 g/L,and KPS score≤80 points points,respectively.Conclusion:Lung cancer patients are at risk of complicating lung infections at the end of radiotherapy treatment,and the pathogenic bacteria are more common in Staphylococcus spp.The indepen-dent risk factors affecting the complication of lung infection after radiotherapy are age＞55 years,radiotherapy time＞2 weeks,combined chemotherapy drugs,albumin content≤30 g/L and KPS score≤80 points.Clinical intervention measures should be taken in time according to the influencing factors,and anti-infective drugs should be rationally selected according to the distribution of pathogenic bacteria to further improve the prevention and treatment of lung infection.
Lung cancerRadiotherapy and chemotherapyPulmonary infectionInfluencing factorsPathogenic bacteria
万方数据
维普
