Correlative Study of the Effect of Pramipexole on Quality of Life Scale Scores and Non-motor Symptoms in Patients with Parkinson's Disease
Objective:To study the effects of pramipexole on Quality of Life Scale(PDQ-39)scores and non-motor symptoms in patients with Parkinson's disease(PD).Methods:128 cases of PD patients admitted to the hospital from June 2019 to December 2021 were selected as study subjects and randomly divided into 62 cases in the control group and 66 cases in the observation group.The control group was treated with dobasic hydrazide tablets orally,and the observation group was treated with pramipexole on the basis of the control group.The PDQ-39 scores,the Brief Mental State Examination(MMSE)scores and the Hamilton Depression Scale(HAMD)scores were compared before and after the treatment of the two groups of patients,the improvement of the non-motor symptoms such as urinary disorders,sensory abnormalities,sleep disorders,sexual dysfunction,and constipation in the two groups were compared,and the incidence of the adverse drug reactions was compared between the two groups of patients.Results:After treatment,the PDQ-39 and HAMD scores of the observation group were lower than those of the control group,and the difference was statistically significant(t=4.678,3.284,P＜0.05).There was no statistically significant difference between the MMSE scores of the two groups(t=5.581,P＞0.05).After treatment,the incidence of urination disorder,sensory abnormality,sleep disorder and sexual dysfunction in the observation group was lower than that in the control group,and the difference was statistically significant(x2=4.486,5.517,3.264,2.524,P＜0.05).The difference in the incidence of constipation between the two groups was not statistically significant(x2=6.521,P＞0.05).The difference in the total incidence of adverse reactions such as insomnia,hypotension,cardiac arrhythmia and gastrointestinal reactions was not statistically significant when comparing the two groups(x2=0.182,P＞0.05).Conclusion:Pramipexole treatment of PD patients can significantly improve their quality of life,improve their non-motor symptoms such as urinary disorders,sensory abnormalities,sleep disorders,sexual dysfunction,and the clinical effect is remarkable.
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维普
