Expression and Clinical Significance of T Lymphocytes,Interleukin-28B and Golgi Protein 73 in Patients with Hepatitis B-associated Hepatocellular Carcinoma
Objective:To analyze the expression and clinical significance of T lymphocytes,interleukin-28B(IL-28B)and Gol-gi protein 73(GP73)in patients with hepatitis B-associated hepatocellular carcinoma.Methods:119 cases of hepatitis B-associated hepatocellular carcinoma patients admitted to the hospital from October 2018 to October 2021 were selected to be included in the observation group,and 112 healthy people who underwent physical examination in the same period were selected to be included in the control group.Serum IL-28B,GP73 and T-lymphocyte levels were compared between the two groups,and the relationship between IL-28B,GP73 and T-lymphocytes and pathological features and prognosis was analyzed.Results:The serum IL-28B,GP73 and CD8+ expression levels of the observation group were higher than those of the control group,and CD3+,CD4+ and CD4+/CD8+ were lower than those of the control group,and the differences were statistically significant(t=148.380,13.155,9.827,9.939,16.367,11.453;P<0.05).There was no statistically significant difference in the comparison of serum levels of IL-28B and GP73 in patients with HBV-associated hepatocellular carcinoma of different ages,genders and tumor diameters(P>0.05).Serum levels of IL-28B and GP73 were higher in those with lymph node metastasis,TNM stage Ⅲ～Ⅳ,low differentiation,and with vascular infiltration than in those without lymph node metastasis,TNM stage Ⅰ～Ⅱ,moderate/high differentiation,and with or without vascular infiltration,and the difference was statistically significant(P<0.05).The differences in serum CD3+,CD4+,and CD8+ in patients with HBV-associated hepatocellular carcinoma were not statistically significant in different ages,genders,and tumor diameters(P>0.05).The differences in CD3+,CD4+,and CD8+ levels were not statistically significant in different lymph node metastasis,TNM stage,differentiation degree,and vascular infiltration(P>0.05).The serum GP73 and IL-28B levels of the deceased were higher than those of the survivors,and the CD4+/CD8+ indexes were lower than those of the survivors,with statistically significant differences(t=16.629,2.082,9.267;P<0.05).Conclusion:Hepatitis B-associated hepatocellular carcinoma patients had significantly higher serum IL-28B,GP73 and CD8+ expression levels,and decreased CD3+,CD4+ and CD4+/CD8+ indexes,and the levels of IL-28B,GP73 and CD4+/CD8+ had a close association with the relevant pathologic features and prognosis.
Hepatitis BCancer of the liverT lymphocytesInterleukin-28BGolgi protein 73
万方数据
维普
