Analysis of the Effects of Memantine and Isotretinoin on Serum TNF-alpha,Hs-CRP,IL-6 Levels,and Stratum Corneum Water Content in Patients with Acne Vulgaris
Objective:To investigate the effect of memantine and isotretinoin on serum inflammatory factors and stratum corneum water content in acne patients.Methods:127 cases of facial acne patients admitted to the hospital from September 2019 to June 2021 were selected as the study subjects,and the patients were divided into the control group(n=63)and the study group(n=64)according to the different treatment protocols.The control group was treated with isotretinoin and the study group was treated with memantine combined with isotretinoin,and both groups were treated for 6 weeks.The stratum corneum water content(MCOC),tumor necrosis factor alpha(TNF-α),transepidermal water loss(TEWL),interleukin 6(IL-6),protein content of stratum corneum samples,C-reactive protein(hs-CRP)levels,and adverse reactions were compared between the two groups before and after treatment.Results:After treatment,the study group had lower levels of TEWL and stratum corneum sample proteins and higher levels of MCOC than the control group,with statistically significant differences(t=3.703,2.769,3.504;P＜0.05).After treatment,the levels of TNF-α,hs-CRP,and IL-6 in the study group were lower than those in the control group,and the difference was statistically significant(t=4.280,19.008,3.512,P＜0.05).There was no statistically significant difference in the comparison of adverse reactions between the two groups(χ2=0.401;P＜0.05).Conclusion:Treatment with memantine in combination with isotretinoin was effective in increasing the water content of the stratum corneum,decreasing serum TNF-α,hs-CRP,and IL-6 levels,and improving the symptoms of skin lesions in patients with acne.
MinocyclineIsotretinoinAcneStratum corneum water contentInflammatory factors
NETL
NSTL
万方数据
维普
