Case-control Study of Influencing Factors of the Onset and Prognosis of Patients with Influenza-Associated Aspergillosis
Objective:To investigate the influencing factors of the morbidity and prognosis of patients with influenza-associated aspergillosis(IAA)in order to identify specific risk factors for invasive aspergillosis in the setting of influenza infection.Methods:383 influenza patients admitted to the hospital from January 1,2014 to December 31,2019 were selected as the study subjects,and they were divided into the IAA case group and the non-IAA control group.The general conditions,morbidity and prognostic characteristics of the two groups were compared.Results:The age of the case group was greater than that of the control group,and the difference was statistically significant(t=2.404,P＜0.05).The prevalence of chronic respiratory diseases and cardiovascular diseases in the case group was higher than that in the control group,and patients with a history of smoking in the case group was higher than that in the control group,with a statistically significant difference(χ2=5.093,P＜0.05).The rates of respiratory failure,shock,MODS,and complications in the case group were higher than those in the control group,and the difference was statistically significant(χ2=19.019,4.014;P＜0.05).The viral conversion rate and cure rate of the case group were lower than those of the control group,and the difference was statistically significant(χ2=16.780,34.774;P＜0.05).The APACHEⅡ scores of the case group were higher than those of the control group,and the difference was statistically significant(t= 6.552,P＜0.05).Smoking history was an independent influence on the development of IAA,and patients who had smoked were more likely to get IAA than those who had not smoked.The analysis of IAA prognostic influencing factors showed that smoking history,complications,respiratory failure,APACHEⅡ score,HR,R,and PCT were higher in the death group than in the survival group,and lymphocytes and oxygenation index were lower than in the survival group,and the difference was statistically significant(t=6.552,3.846,4.624,6.556,7.130,2.521;P＜0.05).Conclusion:Smoking history is an independent risk factor for the development of IAA,and patients with influenza who smoke are more likely to develop IAA than non-smokers.Patients with IAA whose vital signs are unstable,who develop complications,and who are critically ill may have a higher risk of death.
Influenza-associated aspergillosisIncidencePrognosisInfluencing factorCase-control study
NETL
NSTL
万方数据
维普
