Effect of Peginterferon Alpha-2b Combined with Tenofovir on Liver Function and Safety in Patients with Hepatitis B
Objective:To explore the effect of peginterferon α-2b combined withtenofovir on liver function and safety in patients with hepatitis B.Methods:96 patients with hepatitis B admitted to the hospital from October 2018 to August 2020 were randomly divided into group A and group B,with 48 cases in each group.Group A was treated with tenofovir dipivoxil tablets,and group B was treated with pegylated interferon on the basis of group A with α-2b treatment.Total bilirubin(TBIL),albumin(ALB),aspartate aminotransferase(AST),alanine aminotransferase(ALT)and interferon of the two groups before and after treatment-γ(IFN-γ),interleukin-10(IL-10),interleukin-4(IL-4)and interleukin-2(IL-2)before and after treatment were compared.The negative rate of hepatitis B virus(HBV)DNA,hepatitis B e antigen(HBeAg),conversion rate and ALT normalization rate were compared between the two groups.The effective rate and adverse reaction rate of the two groups were counted.Results:After treatment,the levels of TBIL,AST,ALT,IL-10 of B group were lower than A group.Albumin(ALB)was increased in both groups,and the increase in group B was greater than that in group A,with statistically significant difference(t=15.629,27.253,30.580,11.761;P<0.05).After treatment,the increase of IFN-γ and IL-2 of B group was higher than A group,IL-10 and IL-4 decreased,and the level of B group was greater than A group,with statistically significant difference(t=20.777,7.614,24.624,1.609;P<0.05).The HBV DNA negative conversion rate,ALT normalizing rate,hepatitis Be antigen(HBeAg)negative conversion rate and HBeAg conversion rate in group B were higher than those in group A,and the differences were statistically significant(χ2= 4.381,4.800,4.019,4.909,P<0.05).The total effective rate of group B was higher than that of group A,and the difference was statistically significant(χ2=4.360,P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(χ2=0.079,P>0.05).Conclusion:Pegylated interferon α-2b combined with tenofovir can effectively improve liver function,regulate immune function and have high safety.
NETL
NSTL
万方数据
维普
