Effect of Inhaled Sevoflurane on Ischemia Reperfusion Injury in Patients with Traumatic Lower Limb Fracture
Objective:To explore the effect of inhalation sevoflurane anesthesia on ischemia-reperfusion injury in patients with traumatic lower limb fracture.Methods:124 patients with traumatic lower limb fractures treated in the hospital from March 2020 to June 2022 were selected as the study subjects.They were divided into observation group and control group by lot,with 62 patients in each group.Both groups were given propofol target controlled infusion anesthesia during the operation.The observation group was given inhalation sevoflurane assisted anesthesia throughout the operation.The basic signs,renal and myocardial tissue functions,immune function changes,the occurrence of ischemia-reperfusion injury and the quality of recovery of two groups were compared.Results:After the operation,the renal function indexes,such as uric acid(UA),urea nitrogen(BUN),blood creatinine(SCR),adrenal cortisol(Cor)of observation group were lower than control group(t=20.984,29.043,15.350,8.682;P＜0.05).Myocardial injury markers,such as myoglobin(Mb),creatine kinase(CK),creatine kinase isoenzyme(CK-MB)and cardiac troponinⅠ(cTnⅠ)of observation group were lower than control group(t=14.695,5.177,19.790,14.086;P＜0.05).The levels of T lymphocyte subsets CD3+,CD4+and CD8+were better than those in the control group,with statistically significant difference(t=12.035,7.605,7.123;P＜0.05).The incidence of renal injury and myocardial injury after the operation was lower than that in the control group,and the difference was statistically significant(x2=6.306,5.994;P＜0.05).After awakening,there was no significant difference between the control group and the Ricker sedation score(SAS),heart rate(HR),mean arterial pressure(MAP)and blood oxygen saturation(SaO2),with statistically significant difference(t=0.922,0.756,1.895,1.808;P＞0.05).Conclusion:The application of inhaled sevoflurane assisted anesthesia in the operation of patients with traumatic lower limb fracture can effectively reduce the occurrence of kidney and myocardial injury after ischemia-reperfusion,and has positive significance in improving the immune function of patients.At the same time,this anesthesia scheme affects the quality of postoperative recovery of patient,and the basic signs after recovery are relatively stable.
万方数据
维普
