Correlation Between Serum ESM-1,HSP 60 Levels and Prognosis of Patients with Radical Gastrectomy for Gastric Cancer
Objective:To investigate the relationship between serum endothelial cell specific molecule-1(ESM-1),heat shock protein 60(HSP 60)and prognosis of patients undergoing radical gastrectomy for gastric cancer.Methods:136 patients with gastric cancer diagnosed in Xinyang Central Hospital from May 2018 to May 2020 and treated with radical gastrectomy were included in this study.On the next day after admission,the serum ESM-1 and HSP 60 levels of patients with gastric cancer were detected.The patients were followed up after operation until May 2022.The prognosis of patients were evaluated,and the correlation between serum ESM-1,HSP 60 and prognosis of patients with radical gastrectomy were analyzed.Results:Among the 136 patients with gastric cancer included,30 had poor prognosis.Serum ESM-1,HSP 60,tumor stage and lymph node metastasis in patients with different prognosis were compared(t=6.235,14.695;x2=2.742,10.566;P＜0.05).The point two column correlation analysis showed that serum ESM-1 and HSP 60 were positively correlated with the prognosis of patients undergoing radical gastrectomy(r=0.632,0.675;P＜0.05).ROC curve of the subjects was drawn.The results showed that serum ESM-1 and HSP 60 had high predictive value for the prognosis of patients undergoing radical gastrectomy,and the predictive ability of the two was positively correlated(r=0.632,0.675;P＜0.05).The combined predictive value of the two was the best(AUC=0.794).Conclusion:Serum ESM-1 and HSP-60 levels are related to the prognosis of patients undergoing radical gastrectomy,and serum ESM-1 and HSP-60 can be used as important indicators to predict the prognosis of patients.
Radical gastrectomyEndothelial cell specific molecule-1Heat shock protein 60Prognosis
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