Value of C-reactive Protein/Albumin and Albumin/Fibrinogen in Patients with Rheumatoid Arthritis
Objective:To investigate the changes and clinical significance of C-reactive protein to albumin ratio(CAR)and albumin to fibrinogen ratio(AFR)in patients with rheumatoid arthritis(RA).Methods:The clinical characteristics and laboratory indexes were retrospectively analyzed which consisted of 106 patients with RA(case group),62 patients with osteoarthralgia(case control group)and 110 physical examination healthy people(healthy control group).Subjects were recruit from Guangzhou Huadu District Maternal and children hospital from May 2018 to April 2022.The RA group was scored by DAS28.Tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),CAR and AFR were compared among the three groups.The correlations between DAS28 score and laboratory indexes of RA patients were analyzed by Spearman correlation.The independent risk factors of RA were evaluated by Logistic regression.The value of independent risk factors for diagnosis of RA was analyzed by ROC curve.Results:TNF-α,IL-6,CAR and AFR among three groups were significantly different(F=198.973,F=183.136,182.196,F=128.232;P＜0.001).The CAR of the case group was higher than that of the case control group,the difference was statistically significant(t=3.070,P=0.003),and the AFR was lower than that of the case control group,the difference was statistically significant(t=2.489,P=0.014).The differences in TNF-α or IL-6 levels between case group and control group were not statistically significant(t=0.773,t=1.349;P＞0.05).CAR was positively correlated with DAS28 score(r=0.754,P＜0.001),while AFR was negatively correlated with DAS28 score(r=-0.568,P＜0.00l).There was no correlation between TNF-α or IL-6 and DAS28 score(r=0.178,r=0.087;P＞0.05).Logistic regression analysis showed that CAR and AFR were independent risk factors for the development of RA.Taking the case control group and the healthy control group as control for ROC curve analysis,the AUC of CAR was 0.855.The cut-off value was 0.55.The sensitivity and specificity for RA were 100％and 65.12％,respectively.The AUC of AFR was 0.821.The cut-off value was 9.31.The sensitivity and the specificity for RA were 75.47％and 79.07％,respectively.Conclusion:Both of CAR and AFR can be regarded as independent risk factors of RA activity and have diagnostic value for RA.
Rheumatoid arthritisC-reactive protein to albumin ratioAlbumin to fibrinogen ratio
万方数据
维普
