Evaluation of Cardiac Injury in Patients with Breast Cancer Before and After Targeted Therapy by Echocardiography and Electrocardiogram
Objective:To explore the effect of echocardiography combined with ECG on the evaluation of cardiac injury in patients with breast cancer before and after targeted therapy.Methods:A total of 76 patients with breast cancer who were received targeted treatment in Xiangdong District Hospital of Traditional Chinese Medicine in Pingxiang City from October 2020 to September 2021 were selected.All patients were evaluated by echocardiography combined with electrocardiogram before and after treatment.The ECG abnormalities were analyzed,and the related indicators of patients with ECG and echocardiography abnormalities before and after treatment were compared.Results:Among 76 patients with breast cancer,24 cases(31.58％)had abnormal ECG after targeted treatment.The HR of patients with abnormal ECG after treatment was higher than that before treatment,and the QTc was longer,with statistically significant difference(t=2.999,2.699;P＜0.05).76 patients with breast cancer developed echocardiographic abnormalities after targeted treatment in 21 cases(27.63％).Compared with those before treatment,the E/A,LVEF,lateral'e,and septal'e of patients with echocardiographic abnormalities after treatment were decreased.The LAVI,LAVmin,LAVmax and tricuspid regurgitation velocity were increased(t=2.944,8.539,2.162,4.268,3.173,6.264,7.133,3.550;P＜0.05).Conclusion:Echocardiography combined with electrocardiogram can be used to evaluate the changes of cardiac injury in patients with breast cancer before and after targeted therapy.The main manifestations of patients are the increase of HR,LAVI,LAVmin,LAVmax,tricuspid regurgitation velocity,the prolongation of QTc,and the decrease of E/A,LVEF,lateral'e,septal'e.It is necessary to pay close attention to the cardiotoxicity generated in targeted therapy.
Breast cancerTargeted therapyHeart injuryEchocardiogramElectrocardiogram
万方数据
维普
