Relationship Between Platelet to Lymphocyte Ratio and Short-term Prognosis of Patients with Gastric Cancer Treated with Neoadjuvant Chemotherapy
Objective:To analyze the relationship between platelet to lymphocyte ratio and short-term prognosis of patients with gastric cancer treated with neoadjuvant chemotherapy.Methods:A total of 100 patients with gastric cancer who were treated in the hospital from February 2019 to December 2022 were selected.The platelet count(PLT),lymphocyte(LYM)and PLR levels of gastric cancer patients before and after chemotherapy were compared.According to the effect of chemotherapy,the patients were divided into good prognosis group and poor prognosis group.The baseline data and PLT,LYM and PLR levels at admission were compared between the two groups.Receiver operating characteristic(ROC)curve was used to analyze the value of PLR in predicting the short-term prognosis of gastric cancer patients after neoadjuvant chemotherapy.Results:After chemotherapy,PLT and PLR levels of gastric cancer patients were significantly lower than those before chemotherapy,LYM was significantly higher than that before chemotherapy(t=8.655,16.439,6.477;P＜0.05).A total of 100 patients with advanced gastric cancer completed 3 cycles of neoadjuvant chemotherapy,including 1 case(1.00％)of complete remission(CR),33 cases(33.00％)of partial remission(PR),47 cases(47.00％)of stable disease(SD),and 19 cases(19.00％)of progressive disease(PD).There were no significant differences in many indicators between the good prognosis group and the poor prognosis group(P＞0.05).There were significant differences in TNM stage,PLT,LYM and NLR levels between the two groups(x2=9.833,t=7.359,5.299,13.055;P＜0.05).The results of ROC curve showed that the area under the curve of PLR was 0.876,the sensitivity was 91.2％,the specificity was 83.4％(95％CI:0.821～0.945),and the best cut-off value was about 153.7(P＜0.05),indicating that PLR could be used as an effective detection index to evaluate the short-term prognosis of gastric cancer patients after neoadjuvant chemotherapy.Conclusion:After neoadjuvant chemotherapy,the PLR level of patients with gastric cancer decreased significantly.The high expression of PLR is not conducive to the prognosis of patients.Therefore,PLR can be detected at early stage to predict the risk of poor prognosis of patients.
Platelet to lymphocyte ratioGastric cancerNeoadjuvant chemotherapyPrognosis
万方数据
维普
