首页|去甲肾上腺素辅助椎管内麻醉对剖宫产术产妇围手术期心功能的影响研究

去甲肾上腺素辅助椎管内麻醉对剖宫产术产妇围手术期心功能的影响研究

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目的:观察去甲肾上腺素(NE)辅助椎管内麻醉对改善剖宫产术产妇围手术期心功能指标的效果.方法:选取2021年2月—2022年2月南阳医学高等专科学校附属中医院行剖宫产术的110例产妇作为研究对象.采用抽签法将患者分为观察组和对照组,每组各55例.两组患者均实施椎管内麻醉,观察组在此基础上采用NE辅助椎管内麻醉,比较两组产妇围手术期心功能变化情况、不良事件发生情况及新生儿娩出情况.结果:观察组产妇麻醉10 min后(T1)、麻醉30 min后(T2)、术毕时(T3)、苏醒后(T4)时平均动脉压(MAP)和心率(HR)低于对照组,心输出量(CO)高于对照组,差异有统计学意义(t=3.062、3.527、3.821、3.657、2.571、3.115、3.251、3.162、2.427、2.402、2.459、2.615,P<0.05);观察组产妇苏醒时间以及新生儿娩出后1 min、5 min、10 min时的Apgar评分与对照组近似,差异无统计学意义(t=1.138、0.202、0.223、0.152,P>0.05);观察组的不良事件发生率(5.45%)低于对照组(16.36%),差异有统计学意义(χ2=6.126,P<0.05).结论:采用NE辅助剖宫产产妇的椎管内麻醉可显著改善其围手术期心功能,NE不会对产妇苏醒情况及新生儿娩出情况产生明显影响,但会显著降低术后低血压、寒战等不良事件发生风险,改善产妇预后.
Effect of Noradrenaline Assisted Intraspinal Anesthesia on Perioperative Cardiac Function in Puerpera Undergoing Caesarean Section
Objective:To observe the effect of norepinephrine(NE)assisted intraspinal anesthesia on improving perioperative cardiac function in puerpera undergoing cesarean section.Methods:110 puerpera who were selected for cesarean section from February 2021 to February 2022 in the hospital were selected as the research objects.They were divided into the observation group and the control group,with 55 cases in each group.The two groups were given intraspinal anesthesia.The observation group used NE assisted intraspinal anesthesia.The changes of cardiac function,adverse events and neonatal delivery in the perioperative period of the two groups were compared.Results:The mean arterial pressure(MAP)and heart rate(HR)of the observation group were lower than those of the control group 10 min after anesthesia(T1),30 min after anesthesia(T2),after surgery(T3)and after recovery(T4),and the cardiac output(CO)was higher than that of the control group.The difference was statistically significant(t=3.062,3.527,3.821,3.657,2.571,3.115,3.251,3.162,2.427,2.402,2.459,2.615;P<0.05).The recovery time and Apgar scores 1 min,5 min and 10 min after delivery in the observation group were similar to those in the control group,with no significant difference(t=1.138,0.202,0.223,0.152;P>0.05).The incidence of adverse events in observation group(5.45%)was lower than that in control group(16.36%),and the difference was statistically significant(χ2=6.126,P<0.05).Conclusion:Intraspinal anesthesia assisted by NE for cesarean section parturients can significantly improve their perioperative cardiac function.NE will not have significant impact on the puerpera's awakening and neonatal delivery,but will significantly reduce the risk of adverse events such as hypotension and chills,so as to improve the puerpera's prognosis.

Cesarean sectionIntraspinal anesthesiaNoradrenalineCardiac functionNeonatal outcomeAdverse event

王双兵、曲沛

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南阳医学高等专科学校附属中医院麻醉科,河南 南阳 473000

剖宫产 椎管内麻醉 去甲肾上腺素 心功能 新生儿结局 不良事件

河南省医学教育项目

2021002231

2024

黑龙江医学
中华医学会黑龙江分会

黑龙江医学

影响因子:0.714
ISSN:1004-5775
年,卷(期):2024.48(11)