中医药干预反流性食管炎相关信号通路因子表达的研究进展
Research Progress of Chinese Medicine Intervention on the Expression of Signaling Pathway Factors in Reflux Esophagitis
王敏 1王爱民 1徐心怡 1杨欣 2吴婷婷 1朱惠萍 1胡绍江 1孙宏文1
作者信息
- 1. 南京中医药大学附属苏州市中医医院,江苏 苏州 215007
- 2. 南京中医药大学附属苏州市中医医院,江苏 苏州 215007;苏州科技城医院中医科,江苏 苏州 215000
- 折叠
摘要
反流性食管炎(RE)是胃食管反流病的一种重要亚型,发病率呈逐年升高的趋势.近年来,中医药对RE的治疗取得了良好的成效,然而RE的发病机制复杂,涉及到的通路繁多,文章主要总结以下NLRP3/Caspase-1,NF-κB、HIF-2α、P38MAPK信号通路以及经方治疗对以上通路的干预作用,为中医药治愈RE提供科学依据.
Abstract
Reflux esophagitis(RE)is an important subtype of gastroesophageal reflux disease,and its incidence is increasing year by year.In recent years,traditional Chinese medicine has achieved good results in the treatment of reflux esophagitis,many scholars have discussed how traditional Chinese medicine intervenes in the mechanism of RE pathway,however,the pathogenesis of RE is complex,involving a wide range of pathways.The study mainly summarizes the following NLRP3/Caspase-1,NF-κB,HIF-2α and P38MAPK signaling pathway and the intervention effect of meridian treatment on the pathway above,providing scien-tific basis for the cure of RE by traditional Chinese medicine.
关键词
反流性食管炎/中医药/信号通路Key words
Reflux esophagitis/Traditional Chinese medicine/Signaling pathway引用本文复制引用
出版年
2024
NETL
NSTL
万方数据