Association of Admission Blood Glucose and Glycemic Variability on Prognosis of Primary Pontine Hemorrhage
Objective:To investigate the association of admission blood glucose and glycemic variability on prognosis of primary pontine hemorrhage.Methods:Clinical data,such as Glasgow coma score(GCS),blood glucose and hematoma volume within 24 h after admission of 100 patients with pontine hemorrhage admitted to the Department of Neurosurgery,Mianzhu People's Hospital from February 2013 to February 2021 were collected.The correlation of related factors with 30-day survival and 90-day neurological recovery of primary pontine hemorrhage was analyzed,and the relationship between admission blood glucose,hematoma volume and GCS on admission was analyzed.Results:Compared with the survival group,the admission GCS score of the 30-day death group was lower,while the admission blood glucose and hematoma volume were higher(χ2=6.742,3.171,6.168;P＜0.05).There was significant difference in admission GCS score and hematoma volume between poor neurological function recovery group and good group(χ2=6.437,6.495;P＜0.05),but no statistically significant difference in admission blood glucose(χ2=1.574,P＞0.05).Logistic regression analysis showed that only admission GCS score was an independent risk factor for 30-day death while GCS score and hematoma volume were influencing factors for 90-day neurological recovery(P＜0.05).Spearman correlation analysis showed that there was positive correlation between admission blood glucose and hematoma volume of pontine hemorrhage(r=0.232,P＜0.05),a negative correlation between admission blood glucose and GCS on admission(r=0.257,P＜0.05),and between hematoma volume and GCS(r=-0.816,P＜0.05).Conclusion:Admission blood glucose and glycemic variability are not independent risk factors for early death and poor 90-day functional prognosis in patients with pontine hemorrhage.However,there is linear correlation between admission blood glucose,hematoma volume and GCS.Patients with high admission blood glucose levels tend to be in an early critical state and higher early mortality.
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