Effect of GSH Intravenous Drip Combined with Hemoperfusion on Patients with Acute Organophosphorus Pesticide Poisoning
Objective:To investigate the effect of reduced glutathione(GSH)intravenous drip combined with hemoperfusion in the treatment of acute organophosphorus pesticide poisoning(AOPP).Methods:60 patients with AOPP in the hospital from January 2020 to January 2023 were selected.According to the treatment methods,the subjects were divided into control group(n=30)and observation group(n=30).The two groups were treated according to the AOPP treatment routine.The control group was treated with hemoperfusion based on the conventional treatment regimen,and the observation group was treated with GSH based on the treatment regimen of the control group.The clinical therapeutic effect,myocardial damage related indexes and liver function of the two groups were observed.Results:The total effective rate of observation group was higher than that of control group(χ2=4.800,P＜0.05).After treatment,serum cholinesterase(ChE)level in 2 groups was higher than that before treatment,and the level in observation group was higher than that in control group(t=4.919,4.675;P＜0.05).After treatment,creatine kinase(CK)and lactate dehydrogenase(LD)levels in 2 groups were decreased compared with before treatment,and the levels in observation group were lower than those in control group(t=3.080,3.280;P＜0.05).Serum aspartate aminotransferase(AST)and serum alanine aminotransferase(ALT)levels in the two groups were lower than before treatment,and the AST and ALT levels in observation group were lower than those in control group(t=2.302,2.114;P＜0.05).Conclusion:Intravenous GSH combined with hemoperfusion in the treatment of AOPP patients can effectively improve the total effective rate of clinical treatment,improve serum ChE level and liver function,and alleviate myocardial injury.
Acute organophosphorus pesticide poisoningHemoperfusionReduced glutathioneMarkers of myocardial injuryLiver function
NETL
NSTL
万方数据
