Observation on the Effect of Tibial Transversal Bone Transfer Combined with Autologous Platelet-rich Plasma in the Treatment of Diabetic Foot Ulcers
Objective:To investigate the therapeutic effect of transverse tibial bone transfer combined with autologous platelet-rich Plasma(PRP)in the treatment of diabetic foot ulcer(DFU).Methods:The clinical data of 100 patients with DFU treated in the hospital from February 2018 to April 2020 were analyzed retrospectively.48 patients treated with PRP were included in the control group,and 52 patients treated with transversal tibial bone transfer+PRP were included in the observation group.The levels of platelet-derived growth factor receptor(PDGFR)subtypes[Platelet-derived growth factor(PDGFR-α),Platelet-derived growth factor(PDGFR-β)]and the effects of wound healing were compared between the two groups.Results:After treatment,the levels of PDGFR-α and PDGFR-β in the two groups were higher than those before treatment,and those in the observation group were higher than control group(t=5.222,4.599;P＜0.05).In the observation group,the bacterial clearance rate,the wound surface reduction rate,the granulation tissue coverage rate and the granulation tissue growth thickness in the control group were higher than those in the control group,with statistically significant difference(t=8.785,5.248,12.319,17.363;P＜0.05).Conclusion:Transverse tibial bone transfer combined with PRP can improve the expression of PDGFR and the healing effect of DFU ulcer.
Diabetic foot ulcerAutologous platelet-richTranstibial bone transferWound repair
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