摘要
目的:通过检验儿童感染诺如病毒的情况,对呼和浩特地区流行病学特点、生理指征和临床表现进行分析研究.方法:选取2018年1月—2021年12月内蒙古自治区妇幼保健院就诊的2337例儿童,使用荧光实时定量聚合酶链式反应(PCR)技术检测病原体,并结合生化实验室生理指标和临床信息,对诺如病毒阳性病例进行临床相关性分析.结果:呼和浩特市儿童感染诺如病毒阳性率为27.25%.儿童感染和环境污染、人口密度有关,儿童中1～3岁阳性率为31.52%,是易感人群,感染多发生在秋、冬季节;阳性患儿在白细胞升高率为46.60%、中性粒细胞比例降低率为62.00%、淋巴细胞比例升高率为 62.00%、降钙素原(PCT)升高率为 6.60%、合并轮状病毒为 4.80%与阴性儿童的(22.40%、10.40%、10.40%、2.00%、12.00%)相比,差异有统计学意义(P＜0.05);在临床症状如发热、腹泻、呕吐、咳嗽、抽搐、嗜睡等方面比较,差异有统计学意义(χ2=12.500、1.119、48.744、18.835、13.325、11.001,P＜0.05);合并其他疾病,在肺炎、病毒性脑炎、皮炎、咽喉炎、心肌炎、癫痫疾病比较,差异有统计学意义(χ2=26.902、10.109、7.883、7.044、19.136、7.740,P＜0.05).结论:呼和浩特是儿童感染诺如病毒高发地区.儿童感染诺如病毒伴有较严重临床指证对其防治工作应予以重视.
Abstract
Objective:To know the epidemiological features,physiological indications and clinical manifestations,in order to test norovirus pathogens of norovirus infection in children in Hohhot.Methods:A total of 2337 children who visited Inner Mongolia Maternal and Child Health Hospital from January 2018 to December 2021 were recruited to conduct pathogens test by fluorescence real-time quantitative PCR technology.Combined with biochemical laboratory physiological indicators and clinical information,the clinical correlation analysis of norovirus positive cases was carried out.Results:The positive rate of norovirusinfection in children of Hohhot was 27.25%.The infection of children was related to environmental pollution and population density.Children aged from 1～3 were the susceptible group,and the infection mostly occurred in autumn and winter.Compared with negative children(22.40%,10.40%,10.40%,2.00%and 12.00%),positive children had increased rates of white blood cells 46.60%,neutrophils 62.00%,lymphocytes 62.00%,PCT 6.60%and combined rotavirus 4.80%,with statistically significant difference(P＜0.05).The difference was statistically significant in clinical symptoms,such as fever,diarrhea,vomiting,cough,convulsion and lethargy,etc(χ2=12.500,1.119,48.744,18.835,13.325,11.001;P＜0.05).The difference was statistically significant in combined other diseases,such as pneumonia,viral encephalitis,dermatitis,laryngitis,myocarditis and epilepsy,etc.,with statistically significant difference(χ2=26.902,10.109,7.883,7.044,19.136,7.740;P＜0.05).Conclusion:Incidence of norovirus infection in children is high in Hohhot.Prevention and treatment of norovirus infection in children with severe clinical evidence should be paid more attention to.
基金项目
内蒙古自治区卫生健康科技计划(2022)(202201146)
NETL
NSTL
万方数据