Pathology and Epidemic Characteristics of Norovirus in Children in Hohhot
Objective:To know the epidemiological features,physiological indications and clinical manifestations,in order to test norovirus pathogens of norovirus infection in children in Hohhot.Methods:A total of 2337 children who visited Inner Mongolia Maternal and Child Health Hospital from January 2018 to December 2021 were recruited to conduct pathogens test by fluorescence real-time quantitative PCR technology.Combined with biochemical laboratory physiological indicators and clinical information,the clinical correlation analysis of norovirus positive cases was carried out.Results:The positive rate of norovirusinfection in children of Hohhot was 27.25%.The infection of children was related to environmental pollution and population density.Children aged from 1～3 were the susceptible group,and the infection mostly occurred in autumn and winter.Compared with negative children(22.40%,10.40%,10.40%,2.00%and 12.00%),positive children had increased rates of white blood cells 46.60%,neutrophils 62.00%,lymphocytes 62.00%,PCT 6.60%and combined rotavirus 4.80%,with statistically significant difference(P＜0.05).The difference was statistically significant in clinical symptoms,such as fever,diarrhea,vomiting,cough,convulsion and lethargy,etc(χ2=12.500,1.119,48.744,18.835,13.325,11.001;P＜0.05).The difference was statistically significant in combined other diseases,such as pneumonia,viral encephalitis,dermatitis,laryngitis,myocarditis and epilepsy,etc.,with statistically significant difference(χ2=26.902,10.109,7.883,7.044,19.136,7.740;P＜0.05).Conclusion:Incidence of norovirus infection in children is high in Hohhot.Prevention and treatment of norovirus infection in children with severe clinical evidence should be paid more attention to.
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