Effect of Dexmedetomidine on the Inhibition of EC50 in Patients with Visceral Pain During Fibrocolonoscopy Monitored by Narcotrend
Objective:To observe the effect of dexmedetomidine on the inhibition of EC50 in patients with visceral pain by propofol under the monitoring of Narcotrend,so as to provide reference for individual anesthetic medication.Methods:60 patients underwent fibrocolonoscopy under general anesthesia in the hospital from January to December 2022 were selected as the research objects.They were divided into dexmedetomidine+propofol test group(group D)and saline+propofol control group(group C),with 30 patients in each group by randomized number method.Using Marsh pharmacokinetic parameters and target controlled infusion of propofol according to Dixon sequential method was performed.Propofol EC50,95％CI,complications of anesthesia and time of awakening were determined by probabilistic unit method.Results:EC50 and 95％CI of group D were lower than group C,with statistically significant difference(P＜0.05).There was no statistically significant difference in complications of anesthesia between the two groups(P＞0.05).Conclusion:Dexmedetomidine can significantly reduce propofol inhibition of EC50 for visceral pain during fibrocolonoscopy.
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