Effect of Adenosine Monophosphate Combined with Interferon on Immunoglobulin Levels in Children with Severe Hand,Foot and Mouth Disease
Objective:To investigate the clinical effects of adenosine monophosphate combined with interferon in children with severe hand,foot and mouth disease and its effect on immunoglobulin levels.Methods:A total of 78 patients with severe HFMD treated from May 2017 to September 2018 were selected and randomly divided into single group and combined group(39 cases in each group).The single group was treated with interferon,and the combined group was treated with vidarabine monophosphate on the basis of the single group.The symptom disappearance time,immunoglobulin level,inflammatory factor level and the occurrence of adverse reactions were compared between the two groups.Results:After treatment,the recovery abatement of fever,limb shaking relief,herpes regression,nerve inoiovement symptom disappearance,and neurological in volvement disappearance time of combined group was shorter than that of single group(t=5.692,7.835,9.195,6.391,8.316;P＜0.05).5 days after treatment,the levels of IgM,IgG and IgA in combined group were higher than those in single group(t=4.284,12.138,2.124;P＜0.05).TNF-a,IL-6,IL-1β and IL-10 were significantly lower than those in single group(t=19.491,7.799,27.673,11.194;P＜0.05).Conclusion:Vidarabine monophosphatate combined with interferon in children with severe hand,foot and mouth disease can shorten the time of symptom improvement,improve the level of immunoglobulin,reduce the level of inflammatory factors,and reduce the incidence of adverse reactions.
Adenosine monophosphateInterferonSevere hand,foot and mouth diseaseImmunoglobulin levelsInflammatory factorsMedicine safety
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