Effect of Semaglutide Injection on Renal Function and Proinflammatory Factors in Patients with Early Diabetic Nephropathy
Objective:To discuss the effect of semaglutide injection on renal function and proinflammatory factors in patients with early diabetic nephropathy(DN).Methods:According to the random number table method,120 patients with early DN who were divided into control group and observation group in the hospital from September 2021 to March 2022,with 60 cases in each group.The control group was given routine treatment,while the observation group was given semaglutide injection treatment(once a week),all the patients were treated continuously for 12 weeks.The fasting blood glucose(FBG),glycosylated hemoglobin(HbAlc),renal function indicators[blood urea nitrogen(BUN),serum creatinine(Cr),urinary albumin creatinine ratio(UACR)]and proinflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]were compared between the two groups.Results:After treatment,the levels of FBG and HbAlc in 2 groups were significantly lower than before treatment,and the observation group was significantly lower than the control group,with statistically significant difference(t=3.162,3.046;P＜0.05).After treatment,the levels of Cr and UACR in 2 groups were significantly lower than before treatment,and the observation group was significantly lower than the control group,with statistically significant difference(t=5.261,8.426;P＜0.05).After treatment,the serum levels of IL-6 and TNF-α in 2 groups were significantly lower than before treatment,and the observation group was significantly lower than the control group,with statistically significant difference(t=3.357,3.814;P＜0.05).Conclusion:The semaglutide injection can effectively control the blood glucose level of patients with early T2DN,improve renal function,and reduce the levels of proinflammatory factors.
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