Clinical Value Analysis of Serum PCT,CTX-Ⅱ and OPG in the Diagnosis of Postmenopausal Osteoporosis
Objective:To analyze the diagnostic value of serum pro Calcitonin(PCT),C-terminal peptide of type n collagen(CTX-Ⅱ)and osteoprotegerin(OPG)in postmenopausal osteoporosis.Methods:96 postmenopausal osteoporosis patients admitted to the hospital from March 2021 to April 2023 were included in the observation group.90 postmenopausal osteopenia patients admitted to the hospital in the same period were included in the control group,and 89 postmenopausal women with normal bone mass who underwent physical examination in the hospital in the same period were included in the healthy group.Venous blood was collected from three groups,and differences of their serum PCT,CTX-Ⅱ and OPG were detected and compared.Receiver operating curve(ROC)was drawn to analyze the value of detecting and diagnosing postmenopausal osteoporosis.Results:PCT and CTX-Ⅱ in observation group were higher than those in control group and healthy group.OPG was lower than that of control group and healthy group,PCT and CTX-Ⅱ of control group were higher than that of healthy group,and OPG was lower than that of healthy group,with statistically significant difference(F=2682.643,433.038,420.719;P＜0.05).The ROC results showed that the area under the curve(AUC)for the combined diagnosis of PCT,CTX-Ⅱ and OPG in postmenopausal osteoporosis was 0.898,which was higher than the individual diagnoses of 0.829,0.828,and 0.832.Conclusion:PCT,CTX-Ⅱ,and OPG are abnormally expressed in the serum of postmenopausal osteoporosis patients.The combination of the three can effectively diagnose the disease,and provide reliable reference basis for clinical treatment.
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