替罗非班联合常规治疗方案在改善脑梗死损伤中效果及机制的探讨
Study on the Effect and Mechanism of Tirofiban Combined with Conventional Therapy in Improving Cerebral In-farction Injury
任晴 1李金卓 2王贺 2许国振 2李鹏 2杨鹏飞2
作者信息
- 1. 新乡医学院药学院·新乡医学院全过程教学基地,河南 新乡 453003
- 2. 新乡医学院药学院,河南 新乡 453003
- 折叠
摘要
脑梗死是由于急性脑供血不足导致的严重脑损伤,其致残、致死率高,给各个国家都带来了沉重的疾病负担.脑梗死的病理损伤过程包括炎症因子损伤,血小板活化、聚集以及血脑屏障受损等,而血小板聚集又会引起血栓形成,造成严重后果.抗血小板药物替罗非班是一种非肽类血小板Ⅱb/Ⅲa受体拮抗药,直接作用于血小板聚集的最后通路,可以高效地抑制血小板聚集,而且不增加缺血事件的发生.文章从替罗非班联合常规治疗方法缓解患者脑梗死损伤的角度出发,对替罗非班减少炎症因子损伤、减轻血脑屏障受损、减少血小板聚集等药理作用进行探讨,以期为替罗非班在临床使用提供理论支持.
Abstract
Cerebral infarction is a serious brain injury caused by acute cerebral blood supply insufficiency.Its disability and mortality rate are high,which brings heavy disease burden to all countries in the world.The pathological damage process of cerebral infarction includes inflammatory factor damage,platelet activation,aggregation,and blood brain barrier damage,while platelet aggregation can cause thrombosis,causing serious consequences.Tirofiban,an antiplatelet drug,is a non-peptide plateletⅡ b/Ⅲ a receptor antagonist.It directly acts on the final pathway of platelet aggregation,and can effectively inhibit platelet aggregation without increasing the occurrence of ischemic events.The study discusses the pharmacological effects of tirofiban on reducing the damage of inflammatory factors,the damage of blood brain barrier and platelet aggregation from the perspective of tirofiban combined with conventional treatment to alleviate the cerebral infarction injury in patients,in order to provide theoretical support for the clinical use of tirofiban.
关键词
脑梗死/替罗非班/血小板聚集/糖蛋白Ⅱb/Ⅲa受体阻滞剂Key words
Cerebral infarction/Tirofiban/Platelet aggregation/Glycoprotein Ⅱ b/Ⅲ a receptor blocker引用本文复制引用
基金项目
国家自然科学基金(81874312)
河南省自然科学基金(212300410383)
出版年
2024
NETL
NSTL
万方数据