Study on the Efficacy and Safety of Percutaneous Nephrostomy Combined with Scopolamine Bromide in the Treatment of Renal Calculi During Soft Lens Lithotripsy
Objective:To explore the efficacy and safety of minimally invasive percutaneous nephrolithotomy(MPCNL)combined with scopolamine bromide in flexible ureteroscopic lithotripsy(FURL)in the treatment of renal stones.Methods:A total of 80 patients with renal stones admitted to the Kaiyuan Operation Department,the First Affiliated Hospital of Henan University of Science and Technology from July 2021 to November 2022 were randomly divided into two groups,with 40 patients in each group.The control group was treated with FURL combined with scopolamine bromide,while the observation group was treated with MPCNL on the basis of the control group.The clinical efficacy,efficacy and rehabilitation indicators,factors related to renal injury[cluster protein(CLU),kidney injury molecule-1(KIM-1),serum creatinine(SCr)]and risk of complications were compared between the two groups before and after surgery.Results:The clinical effective rate in the observation group(97.50％)was significantly higher than that in the control group(80.00％)with statistically significant difference(x2=6.135,P＜0.05).The operation time in the observation group was longer than that in the control group,while the hospitalization,stone removal,and renal colic relief time in the observation group were shorter than those in the control group(t=15.090,5.755,8.596,6.043;P＜0.05).After surgery,CLU,KIM-1,and SCr increased significantly in both groups,and the ascensional range in the observation group was lower than that in the control group(t=2.761,6.704,3.079;P＜0.05).The risk of complications in the observation group(5.00％)was significantly lower than that in the control group(20.00％)with statistically significant difference(x2=4.114,P＜0.05).Conclusion:MPCNL combined with scopolamine bromide is effective in the treatment of renal calculi with FURL,which can improve the efficiency and safety of stone removal,shorten the recovery time,and reduce the risk of renal injury.
NETL
NSTL
万方数据
