Estradiol/Testosterone Prediction of Postoperative Recurrence in Patients with Endometrial Polyps Undergoing Hysteroscopy
Objective:To explore the predictive value of estradiol(E2)/total testosterone(T)for postoperative recurrence of endometrial polyps in patients undergoing hysteroscopy,and to provide theoretical reference for clinical prevention of recurrence.Methods:A prospective study was conducted,and 153 patients with endometrial polyps who underwent hysteroscopic endometrial polypectomy in Xinyang People's Hospital from January 2020 to January 2022 were selected as the study subjects.On the 7th day of the first menstrual cycle after surgery,the patient's E2 and T levels were measured,E2/T levels were calculated,relevant indicators were statistically analyzed.14 month follow-up was conducted.The patient was divided into a recurrent group and a non recurrent group based on whether the disease recurred during the follow-up period.The baseline data of the two groups were compared.Logistic regression analysis was used to test the influencing factors of recurrence after hysteroscopy in patients with endometrial polyps,and the receiver operating curve(ROC)was drawn to analyze the predictive value of E2/T for recurrence after hysteroscopy in patients with endometrial polyps.Results:Among 153 patients,40 had recurrence,with a recurrence rate of 26.14％.There was statistical significant difference in E2,T,E2/T,estrogen receptor(ER),cyclooxygenase-2(COX-2)between the recurrent group and the non recurrent group(t=6.111,2.061,7.399;x2=5.239,5.687;P＜0.05).Logistic regression analysis showed that E2,T,E2/T and ER were the relevant factors affecting postoperative recurrence in patients with endometrial polyps(P＜0.05).ROC analysis showed that E2 and E2/T had moderate predictive value for postoperative recurrence,with area under the curve(AUC)of 0.784 and 0.806,respectively.T had a low predictive value for postoperative recurrence,with AUC of 0.608.Conclusion:E2/T can be used as a clinical indicator to predict postoperative recurrence in patients with endometrial polyps.
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