Diagnostic Value of Squamous Cell Carcinoma Antigen,Cytokeratin 19 and Serum Response Factor in Lymph Node Metastasis of Esophageal Cancer
Objective:To investigate the diagnostic value of squamous cell carcinoma antigen(SCC),cytokeratin 19(CYFRA21-1)and serum response factor(SRF)in lymph node metastasis of esophageal cancer(EC).Methods:The clinical data of 128 patients with esophageal cancer who were treated in Luoyang Oriental People's Hospital from February 2019 to January 2021 were retrospectively analyzed.According to the lymph node metastasis of the patients,they were divided into lymph node metastasis group and non lymph node metastasis group.Clinical data of the patients were compared.And the correlation between SCC,CYFRA21-1 and SRF in patients with esophageal cancer and lymph node metastasis in patients with esophageal cancer was analyzed.The area under receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of SCC,CYFRA21-1 and SRF in lymph node metastasis of esophageal cancer.Results:Among the 128 patients with esophageal cancer included in this study,40 patients developed lymph node metastasis,and the incidence of lymph node metastasis was 31.25％.Compared with no lymph node metastasis group,there was no significant difference in age,sex,BMI,place of residence,marital status,education level,smoking,drinking,lesion site,tumor length,hypertension and diabetes in the group with lymph node metastasis(t/x2=0.302,0.236,1.283,0.145,0.348,0.348,0.984,0.046,0.029,0.332,2.086,0.398,1.112;P＞0.05).There was statistically significant difference in TNM staging,tumor differentiation,SCC,CYFRA21-1 and SRF,etc(4/x2=6.188,5.593,7.435,7.160,8.503;P＜0.05).Logistic regression analysis showed that the degree of tumor differentiation,SCC,CYFRA21-1 and SRF were all risk factors for lymph node metastasis(r=0.645,0.667,0.658;P＜0.05).The area under the curve AUC of SCC,CYFRA21-1 and SRF for predicting lymph node metastasis was 0.666,0.860 and 0.883,respectively.The AUC of SCC,CYFRA21-1 and SRF for predicting lymph node metastasis was 0.952,which was higher than that of each index alone.The difference was statistically significant(P＜0.05).Conclusion:SCC,CYFRA21-1 and SRF are highly correlated with the occurrence of lymph node metastasis.And the combined detection of SCC,CYFRA21-1 and SRF is better than the detection of each index alone.
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