Influencing Factors of Flash-visual Evoked Potentials of Children with Severe Neonatal Hyperbilirubinemia
Objective:To retrospectively analyze the influencing factors of flash visual evoked potential(F-VEP)of children with severe neonatal hyperbi lirubinemia.Methods:Searching neonates with severe hyperbilirubinemia who were hospitalized in NICU of the hospital from January 2019 to December 2021 to find out the children who had completed simultaneous peripheral arteriovenous exchange transfusion treatment and underwent F-VEP examination.The data were recorded,such as the results of F-VEP,gestational age,weight and age at blood exchange,serum total bilirubin level and direct bilirubin level before blood exchange,serum total bilirubin level and direct bilirubin level after blood exchange and total days of hospital stay,etc.According to the results of F-VEP,all the neonates were divided into two groups:abnormal F-VEP group and normal F-VEP group,and the data were compared.Results:A total of 73 neonates with severe jaundice were found who underwent F-VEP examination after simultaneous peripheral arteriovenous exchange transfusion treatment,of which 3 neonates were treated with 2 times of exchange transfusion treatment.As a result,there were a total of 76 times of exchange transfusion and 73 times of F-VEP.21 of the 73 times were abnormal F-VEP and 52 times were normal F-VEP.Gestational age and body weight in the abnormal F-VEP group were lower than those in the normal F-VEP group,and the differences between the two groups were statistically significant(t=-2.317,-2.078;P＜0.05).Serum total bilirubin(TSB)level before blood exchange,direct bilirubin(DB)level before blood exchange,serum total bilirubin level after blood exchange,age when blood exchange in abnormal F-VEP group were lower than those in the normal F-VEP group respectively.However,there was no statistical significance between the two groups(t=-0.408,-0.816,-0.788,0.121;P＞0.05).The level of direct bilirubin(DB)after blood exchange in the group with abnormal F-VEP was higher than that in the group with normal F-VEP,with no significant difference between the two groups(t=-0.121;P＞0.05).The length of hospital stay of newborns in the abnormal F-VEP group was smaller than that in the normal F-VEP group,but the difference was not statistically significant between the two groups(t=-0.079,P＞0.05).Conclusion:Some neonates with severe hyperbilirubinemia and undergoing exchange transfusion have abnormal F-VEP,and children with small gestational age and low body weight during blood exchange ware more likely to have abnormal F-VEP.Therefore,it is necessary to strengthen the monitoring of F-VEP for infants with severe jaundice of small gestational age and low body weight,in order to find the abnormal condition of F-VEP and treat in time.
Severe neonatal hyperbilirubinemiaExchange transfusionFlash-visual evoked potentialsGestational age
NETL
NSTL
万方数据
