Effects of Preoperative Dexmedetomidine Pretreatment on Depth of Anesthesia,Cerebral Oxygen Metabolism and Extubation Safety During Orthopedic General Anesthesia
Objective:To observe the effects of preoperative dexmedetomidine pretreatment on depth of anesthesia,cerebral oxygen metabolism and extubation safety during orthopedic general anesthesia.Methods:A total of 84 orthopedic surgery patients in the hospital from March 2020 to March 2022 were enrolled and divided into observation group and control group by random number table method,with 42 cases in each group.The observation group was preinjected with 1μg/kg dexmedetomidine before induction of anesthesia,while the control group was preinjected with the same volume of normal saline.Anesthesia use and extubation time,heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),anesthesia depth index(CSI),cerebral oxygen metabolism indexes[arterial oxygen content(CaO2),venous oxygen content(CvO2)]at different time points[before induction of anesthesia(T0),1 min before extubation(T1),at extubation(T2),and 10 min after extubation(T3)],observer assessment of sedation(OAA/S)score at T2,cough severity score,and the occurrence of adverse reactions were compared between the two groups.Results:The intraoperative dosage of remifentanil and propofol in the observation group were lower than those in the control group(t=3.942,4.724;P＜0.05).SBP and HR at T1,T2 and T3,DBP at T2 and T3 in the observation group were lower than those in the control group(t=7.976,9.185,5.073,5.192,6.842,4.163,4.604,3.823;P＜0.05).The CSI at T0,T1 and T2 in the observation group was lower than that in the control group,and the difference was statistically significant(t=50.606,3.609,2.407;P＜0.05).CaO2 and CvO2 in the two groups at T2 were lower than those at T1,but were higher in the observation group than in the control group(t=9.252,6.384;P＜0.05).CaO2 and CvO2 at T3 were higher than those at T2,and the observation group was higher than the control group,with statistically significant difference(t=7.514,2.460;P＜0.05).Conclusion:Pre-injection of dexmedetomidine before orthopedic general anesthesia can reduce the dosage of general anesthesia drugs,stabilize perioperative hemodynamics,improve cerebral oxygen metabolism,maintain the ideal depth of anesthesia,and reduce stress response during extubation.
DexmedetomidineOrthopaedic surgeryGeneral anesthesiaDepth of anesthesiaCerebral oxygen metabolismSafety of extubation
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